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I recently took a drive from Houston to San Antonio in my 2007 MCS. I took the old route, Highway 90 instead of Interstate 10. 90 essentially parallels 10 the entire way just about 20 miles south of it the whole time. Highway 90 passes through many small, interesting central texas towns including Shiner which is where the Shiner brewery is, where you can go in for a tour and they'll pour you a good ol' Shiner Bock and tell you about the heritage of the company. There are lots of empty stretches of road with many hills and a few twisties. I recommend this drive to anyone who is going from SA to Houston or vice versa, it definitely beats the interstate.